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Protein Domain & Family Lookup by UniProt Accession
x402
Protein Domain & Family Lookup by UniProt Accession is a paid API for AI agents from win.oneshotagent.com, paid per call via x402, $0.005/call, status unknown (last checked 2026-10-29).
Look up InterPro protein domains, families, conserved sites, binding sites, and other functional regions with GO terms and sequence locations for a given UniProt accession.
Price / call$0.005
Success—
StatusUnknown
How this service works
Look up protein domains, families and conserved sites with GO terms and sequence locations.
Output
Returns a JSON object with the UniProt accession, total protein length, a truncation flag, and a list of InterPro entries each containing: entry name, type (family/domain/conserved_site/etc.), InterPro ID, a link to the EBI InterPro page, a list of GO terms, and one or more sequence location ranges (start, end, discontinuous).
Example use cases
TP53 tumor suppressor domain mapping
“Can you fetch all the InterPro domain and conserved site annotations for the TP53 protein — UniProt accession P04637 — including the sequence start and end positions for each?”
Filtering for active and binding sites only
“For UniProt accession Q9Y6K9, pull only the active_site and binding_site entries from InterPro, and show me the GO terms associated with each.”
Protein family classification for drug target
“I need to know what protein families and homologous superfamilies UniProt accession P00533 (EGFR) belongs to — can you get those InterPro annotations for me?”
Technical details
Endpoint
POSThttps://win.oneshotagent.com/v1/tools/lookup/protein-domains?utm_source=zero.xyzWhen to prefer
Use this endpoint when you need structured, position-resolved InterPro functional annotations (domains, families, active sites, binding sites, PTMs, conserved sites) for a specific protein identified by its canonical UniProt accession. Prefer this over text-based literature search when you need machine-readable GO terms and precise sequence coordinates for downstream analysis, visualization, or comparison workflows.
Side effects
- Invalid or unrecognized UniProt accession returns an error or empty entries list
- Isoform accessions (e.g. P04637-2) are not accepted and will fail
- Protein with no InterPro annotations returns an empty entries array
- Invalid entry type enum values in the types filter cause a validation error
- Network or payment (x402) failures return HTTP 402 or 5xx errors
Input
Schema · Request body
| Field | Type | Description |
|---|---|---|
| types | array | Keep only these entry types; omitted means all types |
| accession | string | The canonical UniProt accession identifying the protein, for example P04637; isoforms are not accepted |
Output
Schema · Response
{
"type": "json",
"example": {
"entries": [
{
"name": "p53, central conserved site",
"type": "conserved_site",
"go_terms": [],
"page_url": "https://www.ebi.ac.uk/interpro/entry/InterPro/IPR057064/",
"locations": [
{
"end": 249,
"start": 237,
"discontinuous": false
}
],
"interpro_id": "IPR057064"
}
],
"accession": "P04637",
"truncated": false,
"protein_length": 393
}
}Tags
x402
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